Occupational Toxicology: NIOSH Perspective

  title={Occupational Toxicology: NIOSH Perspective},
  author={Barry L. Johnson},
  journal={International Journal of Toxicology},
  pages={43 - 50}
HIS article will address one specific area of toxicology, occupational toxicology. The plan is to T present an overview of the NIOSH’s activities in the area of occupational toxicology. In so doing, the paper will describe details of the NIOSH’s research that bear on development and management of our occupational toxicology program, as well as its present views on rationale for testing. In addition, some general views bearing on the roles of government, private industry, and labor in the matter… Expand
5 Citations
A strategy for delineating risks due to exposure to neurotoxic chemicals.
A method for delineating the risks due to exposure to neurotoxic chemicals based upon the linkage of four national computer-based registers is described, and 18 chemicals are identified as "risk chemicals," primarily used in 8 main groups of products. Expand
Introduction Screening for Neurotoxicity: Principles and Practices
The early and incipient stages of intoxication produced by environmental agents are frequently marked by vagueness and ambiguity, and many complaints are subjective, so the potential for the occurrence of subtle, undetected effects is currently unknown. Expand
Alternative Methods and Their Application in Neurotoxicity Testing
It has been estimated that there are approximately 4–5 million chemical compounds in the environment, with around 50,000–60,000 in common industrial use (1). Up to 1,000 new chemicals enter commerceExpand
New models for the In vitro assessment of neurotoxicity in the nervous system and the preliminary validation stages of a 'tiered-test' model.
In vitro exposure of xenobiotics through a tiered testing system (ranging from simple cell-based assays measuring cytotoxicological parameters to more complex markers in organotypic cultures) may permit detection of central nervous system neurotoxicity in the contexts of both 'screening' and mechanistics. Expand
Use of pharmaceuticals in industrial workers — possible implications for epidemiological studies
A classification system for possible ( side) effects of pharmaceuticals was developed, taking the dose into account, and potential (side) effects that occurred significantly more frequently in the exposed than in the non-exposed were: tiredness, sedation, dizziness. Expand


Carcinogenicity and toxicity of 1,2-dibromoethane in the rat.
Testicular atrophy was found in 90% of the male rats that received a combination of EDB and disulfiram treatment and caused high incidences of tumors in liver, spleen, kidney, adrenal, thyroid, lung, mesentery, and mammary gland in one or both sexes. Expand
Toxicity and metabolism of methyl n-butyl ketone.
MBK in rat plasma after exposure to MBK/MEK increased with time and metabolites of MBK identified in blood and urine of rats and guinea pigs were 2-hexanol and 2,5-hexanedione. Expand
Reproductive toxicity of the glycol ethers.
The glycol ethers are an important and widely used class of solvents and structure-activity relationships are speculated upon. Expand
National Institute for Occuapational Safety and Health- Mission Statement
  • 1982
Controlling toxics
  • EPA Journal, pp. 12.15,
  • 1979