Occupational Exposure Risks in Individuals with PI*Z α1-Antitrypsin Deficiency

@article{Mayer2000OccupationalER,
  title={Occupational Exposure Risks in Individuals with PI*Z $\alpha$1-Antitrypsin Deficiency},
  author={Annyce S Mayer and James K Stoller and Becki Bucher Bartelson and A. James Ruttenber and Robert A Sandhaus and Lee S. Newman},
  journal={American Journal of Respiratory and Critical Care Medicine},
  year={2000},
  volume={162},
  pages={553-558}
}
We obtained questionnaire and spirometry data from 128 α1-antitrypsin ( α1AT)-deficient individuals with phenotype PI*Z to examine the relationship between chronic respiratory symptoms, airflow limitation, treatment requirements, and semiquantitative estimates of occupational exposure to dust, fumes, smoke, and gas. After adjusting for age, smoking, and prior lower respiratory tract infections, increased prevalence of chronic cough (OR = 4.69, 95% CI = 1.57–13.74, p = 0.006) and having left a… 
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α1-Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants
Chronic obstructive pulmonary disease (COPD) is a prevalent and preventable disease associated with high morbidity and mortality. Severe and intermediate α1-antitrypsin (AAT) deficiency (serum levels…
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Patients with α1-antitrypsin disease should be assessed for occupational exposures and closely monitored for work-accelerated progression of lung function decline, underscoring that work-associated pulmonary disease can be multi-factorial.
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The evidence about the risks of the MZ population to develop emphysema or asthma is summarized, and it is suggested thatAugmentation therapy in MZ individuals is not supported by any objective studies.
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High exposure to gases or fumes was associated with chronic bronchitis, and high exposure to all occupational agents was consistently associated with better diffusion capacity in long-term quitters.
Environmental, occupational, and genetic risk factors for alpha-1 antitrypsin deficiency.
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Sibling pairs, particularly those with discordant disease or concordant parenchymal disease, are an ideal group to further investigate the contribution of other genes in the development of COPD or its phenotype in AATD patients.
Rare &agr;1-antitrypsin genotype in a grass seed worker
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A case of chronic obstructive pulmonary disease (COPD) caused by a combination of occupational dust exposure and severe α1-antitrypsin (α1-AT) deficiency and an apparent PiMM genotype was revealed to be heterozygotic for two different rare deficient alleles.
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