Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.

Abstract

Potentiating neuroactive steroids are potent and efficacious modulators of the GABA(A) receptor that act by allosterically enhancing channel activation elicited by GABA. Steroids interact with the membrane-spanning domains of the α subunits of the receptor, whereas GABA binds to pockets in the interfaces between β and α subunits. Steroid interaction with a… (More)
DOI: 10.1124/mol.111.071662

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@article{Bracamontes2011OccupationOE, title={Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site.}, author={John R. Bracamontes and Megan M McCollum and Caroline E Hogen Esch and Ping Li and Jason Ann and Joe Henry Steinbach and Gustav Akk}, journal={Molecular pharmacology}, year={2011}, volume={80 1}, pages={79-86} }