Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography
@article{Schotte1993OccupancyOC, title={Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography}, author={Alain Schotte and Paul F. M. Janssen and Anton A Megens and Jos{\'e}e E. Leysen}, journal={Brain Research}, year={1993}, volume={631}, pages={191-202} }
212 Citations
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding
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Risperidone and its active metabolite 9-OH-risperidone were compared to reference antipsychotic drugs (haloperidol, pipamperone, fluspirilene, clozapine, zotepine) and compounds under development…
Biochemical evidence that the atypical antipsychotic drugs clozapine and risperidone block 5-HT2C receptors in vivo
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Risperidone Dose-Dependently Increases Extracellular Concentrations of Serotonin in the Rat Frontal Cortex: Role of α2 –Adrenoceptor Antagonism
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Risperidone: regional effects in vivo on release and metabolism of dopamine and serotonin in the rat brain
- Biology, PsychologyPsychopharmacology
- 2005
In contrast to the regionally rather homogenous activation of brain DA systems caused by risperidone, the drug was found to enhance brain 5-HT metabolism preferentially in the MPC, as indicated by the elevated extracellular concentration of 5-HIAA in this region.
Effect of clozapine and risperidone on 5-HT2 and D2-dopamine receptor binding in the post-mortem human brain. An autoradiographic study
- Psychology, MedicineEuropean Neuropsychopharmacology
- 1995
Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine.
- Biology, MedicineLife sciences
- 2007
Survey on the pharmacodynamics of the new antipsychotic risperidone
- Biology, PsychologyPsychopharmacology
- 2005
Risperidone can be characterized as a potent D2 antagonist with predominant 5HT2 antagonistic activity and optimal pharmacokinetic properties.
In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used.
- Psychology, MedicineJapanese journal of pharmacology
- 1995
The predominant 5-HT2A-receptor occupancy most likely underlies risperidone's beneficial effects on the negative symptoms of schizophrenia and an adequately low D2-receptors occupancy adds to the treatment of positive symptoms with a low liability of EPS.
Selective effects on prefrontal cortex serotonin by dopamine D3 receptor agonism: Interaction with low-dose haloperidol
- Psychology, MedicineProgress in Neuro-Psychopharmacology and Biological Psychiatry
- 1997
In vivo 5-HT6 receptor occupancy by antipsychotic drugs in the rat brain
- Psychology, MedicineNeuroscience Letters
- 2011
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