Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility

@inproceedings{Dogan2015OccupancyBK,
  title={Occupancy by key transcription factors is a more accurate predictor of enhancer activity than histone modifications or chromatin accessibility},
  author={Nergiz Dogan and Weisheng Wu and Christapher S. Morrissey and Kuan-Bei Chen and Aaron J. Stonestrom and M. Scott Long and Cheryl A. Keller and Yong Cheng and Deepti P. Jain and Axel Visel and Len A. Pennacchio and Mitchell J Weiss and Gerd A Blobel and Ross C. Hardison},
  booktitle={Epigenetics & Chromatin},
  year={2015}
}
Regulated gene expression controls organismal development, and variation in regulatory patterns has been implicated in complex traits. Thus accurate prediction of enhancers is important for further understanding of these processes. Genome-wide measurement of epigenetic features, such as histone modifications and occupancy by transcription factors, is improving enhancer predictions, but the contribution of these features to prediction accuracy is not known. Given the importance of the… CONTINUE READING