Occult senile cardiac amyloid in severe calcific aortic stenosis is not rare and has a poor prognosis: a 146 patient CMR biopsy study

Background Severe degenerative calcific aortic stenosis (cAS) affects 3% of the over 75 year-olds and leads to heart failure and death unless the valve is replaced. Coexisting cardiac amyloid typically wild-type Transthyretin (wtATTR) has been reported but has not been systematically studied: its prevalence and prognostic significance are unknown… CONTINUE READING