Occult hepatitis B virus infection in HBs antigen-negative hepatocellular carcinoma in a Japanese population: involvement of HBx and p53.

@article{Shiota2000OccultHB,
  title={Occult hepatitis B virus infection in HBs antigen-negative hepatocellular carcinoma in a Japanese population: involvement of HBx and p53.},
  author={Goshi Shiota and Kenji Oyama and Akihide Udagawa and Katsuaki Tanaka and Takahiro Nomi and Akio Kitamura and Atsushi Tsutsumi and Noya Noguchi and Yuji Takano and Kazuo Yashima and Yosuke Kishimoto and Takeaki Suou and Hironaka Kawasaki},
  journal={Journal of medical virology},
  year={2000},
  volume={62 2},
  pages={151-8}
}
Hepatitis B virus (HBV) genome was reported to be detected in serum or liver tissues in hepatocellular carcinoma (HCC) patients negative for hepatitis B surface antigen (HBsAg). Hepatitis B x (HBx) and p53 protein were reported to play an important role in HBV-related hepatocarcinogenesis. To clarify latent HBV infection in HBsAg- and anti-hepatitis C virus (anti-HCV)-negative HCC in a Japanese population and involvement of HBx and p53 protein in these patients, we performed the sensitive and… CONTINUE READING