Occlusion of Regulatory Sequences by Promoter Nucleosomes In Vivo

@inproceedings{Mao2011OcclusionOR,
  title={Occlusion of Regulatory Sequences by Promoter Nucleosomes In Vivo},
  author={Changhui Mao and Christopher R. Brown and Joachim Griesenbeck and Hinrich Boeger},
  booktitle={PloS one},
  year={2011}
}
Nucleosomes are believed to inhibit DNA binding by transcription factors. Theoretical attempts to understand the significance of nucleosomes in gene expression and regulation are based upon this assumption. However, nucleosomal inhibition of transcription factor binding to DNA is not complete. Rather, access to nucleosomal DNA depends on a number of factors, including the stereochemistry of transcription factor-DNA interaction, the in vivo kinetics of thermal fluctuations in nucleosome… CONTINUE READING

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