Occludin phosphorylation in regulation of epithelial tight junctions.

  title={Occludin phosphorylation in regulation of epithelial tight junctions.},
  author={RadhaKrishna Rao},
  journal={Annals of the New York Academy of Sciences},
Occludin is the first transmembrane protein of the tight junction to be discovered. While numerous studies emphasized the important role of occludin in assembly and maintenance of tight junctions, occludin knockout studies indicated that it was not required for tight junction assembly in different epithelia. However, a detailed characterization of the occludin knockout mouse concluded that the occludin gene is indispensable, and plays a complex role in regulation of epithelial tight junctions… CONTINUE READING


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PKCη plays a role in occludin phosphorylation and regulation of tight junction integrity

  • T Suzuki
  • Proc. Natl. Acad. Sci. USA
  • 2009

Phosphorylation of Y398 and Y402 in occludin prevents its interaction with ZO-1 and attenuates its assembly into tight junctions (TJ)

  • Elias, B.C
  • J. Biol
  • 2009

Critical role of the atypical {lambda} isoform of protein kinase C (PKC{lambda}) in oxidant-induced disruption of the microtubule cytoskeleton and barrier function of intestinal epithelium

  • A Banan
  • J. Pharmacol. Exp. Ther
  • 2005

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