Occludin modulates transepithelial migration of neutrophils.

  title={Occludin modulates transepithelial migration of neutrophils.},
  author={Denise Huber and Maria Susana Balda and Karl Matter},
  journal={The Journal of biological chemistry},
  volume={275 8},
Neutrophils cross epithelial sheets to reach inflamed mucosal surfaces by migrating along the paracellular route. To avoid breakdown of the epithelial barrier, this process requires coordinated opening and closing of tight junctions, the most apical intercellular junctions in epithelia. To determine the function of epithelial tight junction proteins in this process, we analyzed neutrophil migration across monolayers formed by stably transfected epithelial cells expressing wild-type and mutant… CONTINUE READING