Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).

@article{Runkle2012OccludinIA,
  title={Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).},
  author={E Aaron Runkle and Shawn J. Rice and Ji Qi and Dustin R Masser and David A Antonetti and Monte M Winslow and David Mu},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 34},
  pages={28790-801}
}
The thyroid transcription factor 1 gene (TTF-1 or NKX2-1) is essential to lung development; however, it is also a critical factor in lung cancer. TTF-1 is amplified in lung cancers, suggesting that it is a gain-of-function lung oncogene. Conversely, TTF-1 counters epithelial to mesenchymal transition in cell-based studies and inhibits progression of primary… CONTINUE READING