Occasional physical inactivity combined with a high-fat diet may be important in the development and maintenance of obesity in human subjects.

@article{Shepard2001OccasionalPI,
  title={Occasional physical inactivity combined with a high-fat diet may be important in the development and maintenance of obesity in human subjects.},
  author={Trudy Y Shepard and Kathleen M Weil and Teresa A. Sharp and Gary K. Grunwald and Melanie L Bell and James O Hill and Robert H Eckel},
  journal={The American journal of clinical nutrition},
  year={2001},
  volume={73 4},
  pages={703-8}
}
BACKGROUND A better understanding of the environmental factors that contribute to obesity is imperative if any therapeutic effect on the increasing prevalence of overweight and obesity in the United States is to be achieved. OBJECTIVE This study examined the effect of the interaction of diet composition and physical inactivity on energy and fat balances. DESIGN Thirty-five normal-weight and obese subjects were randomly assigned to either a 15-d isoenergetic high-carbohydrate (HC) or high… CONTINUE READING