Obtaining accurate translations from expressed sequence tags.

  title={Obtaining accurate translations from expressed sequence tags.},
  author={James D Wasmuth and Mark L. Blaxter},
  journal={Methods in molecular biology},
The genomes of an increasing number of species are being investigated through the generation of expressed sequence tags (ESTs). However, ESTs are prone to sequencing errors and typically define incomplete transcripts, making downstream annotation difficult. Annotation would be greatly improved with robust polypeptide translations. Many current solutions for EST translation require a large number of full-length gene sequences for training purposes, a resource that is not available for the… CONTINUE READING