Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance.

@article{Nobili2014ObstructiveSA,
  title={Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance.},
  author={Valerio Nobili and Renato Cutrera and Daniela Liccardo and Martino Pavone and Rita Devito and Valentina Giorgio and Elisabetta Verrillo and Giuseppe Baviera and Giovanni Musso},
  journal={American journal of respiratory and critical care medicine},
  year={2014},
  volume={189 1},
  pages={66-76}
}
RATIONALE Obstructive sleep apnea syndrome (OSAS) and nonalcoholic fatty liver disease (NAFLD) are frequently encountered in obese children. Whether OSAS and intermittent hypoxia are associated with liver injury in pediatric NAFLD is unknown. OBJECTIVES To assess the relationship of OSAS with liver injury in pediatric NAFLD. METHODS Sixty-five consecutive children with biopsy-proven NAFLD (age, mean ± SD, 11.7 ± 2.1 yr; 58% boys; body mass index z score, 1.93 ± 0.61) underwent a clinical… CONTINUE READING
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