Obstructive sleep apnea: role of intermittent hypoxia and inflammation.

  title={Obstructive sleep apnea: role of intermittent hypoxia and inflammation.},
  author={Anna M May and Reena Mehra},
  journal={Seminars in respiratory and critical care medicine},
  volume={35 5},
Obstructive sleep apnea results in intermittent hypoxia via repetitive upper airway obstruction leading to partial or complete upper airway closure, apneas and hypopneas, respectively. Intermittent hypoxia leads to sympathetic nervous system activation and oxidative stress with a resultant systemic inflammatory cascade. The putative mechanism by which obstructive sleep apnea has been linked to numerous pathologic conditions including stoke, cardiovascular disease, hypertension, and metabolic… CONTINUE READING
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