Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes.

@article{Vielhauer2001ObstructiveNI,
  title={Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes.},
  author={Volker Vielhauer and Hans Joachim Anders and Matthias Mack and Josef Cihak and Frank Strutz and Manfred Stangassinger and Bruno Luckow and Hermann Josef Groene and Detlef Schloendorff},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2001},
  volume={12 6},
  pages={1173-87}
}
The infiltration of leukocytes plays a major role in mediating tubulointerstitial inflammation and fibrosis in chronic renal disease. CC chemokines participate in leukocyte migration and infiltration into inflamed renal tissue. Because CC chemokine-directed leukocyte migration is mediated by target cell expression of a group of CC chemokine receptors, this study examined the expression of CC chemokines and their receptors during initiation of tubulointerstitial fibrosis after unilateral… CONTINUE READING

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