Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis

@article{Kyrgiou2006ObstetricOA,
  title={Obstetric outcomes after conservative treatment for intraepithelial or early invasive cervical lesions: systematic review and meta-analysis},
  author={Maria Kyrgiou and George Koliopoulos and Pierre P L Martin-Hirsch and Marc Arbyn and Walter J Prendiville and Evangelos Paraskevaidis},
  journal={The Lancet},
  year={2006},
  volume={367},
  pages={489-498}
}
BACKGROUND Conservative methods to treat cervical intraepithelial neoplasia and microinvasive cervical cancer are commonly used in young women because of the advent of effective screening programmes. In a meta-analysis, we investigated the effect of these procedures on subsequent fertility and pregnancy outcomes. METHODS We searched for studies in MEDLINE and EMBASE and classified them by the conservative method used and the outcome measure studied regarding both fertility and pregnancy… 
Obstetric outcomes after conservative treatment for cervical intraepithelial lesions and early invasive disease.
TLDR
The effect of local cervical treatment for CIN and early cervical cancer on obstetric outcomes and to correlate these to the cone depth and comparison group used was assessed.
Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis
TLDR
There is no evidence suggesting that treatment for cervical intraepithelial neoplasia adversely affects fertility, although treatment was associated with a significantly increased risk of miscarriages in the second trimester.
Adverse Pregnancy Outcomes After Treatment for Cervical Intraepithelial Neoplasia
TLDR
Treatment with major excisional procedures, including LEEP, was associated with increased risks of preterm birth and spontaneous abortion, which was highest at early gestational ages and for those with the largest amount of tissue excised.
Obstetric complications following conservative treatment of Cervical Intraepithelial Neoplasia
Treatment for cervical intraepithelial neoplasia (CIN) has been correlated with adverse reproductive morbidity in subsequent pregnancies. This review provides a summary of the risks, potential
Fertility and early pregnancy outcomes after conservative treatment for cervical intraepithelial neoplasia.
TLDR
The meta-analysis demonstrated that treatment for CIN did not adversely affect the chances of conception and the number of women requiring more than 12 months to conceive.
Preterm Delivery After Surgical Treatment for Cervical Intraepithelial Neoplasia
TLDR
Any treatment for CIN, including loop electrosurgical excision procedure, increases the risk of preterm delivery, and it is important to emphasize this when treating young women with CIN.
The risk of preterm birth of treated versus untreated cervical intraepithelial neoplasia (CIN): a systematic review and meta-analysis.
TLDR
The increased risk of PTB in women who underwent cervical surgery for CIN is especially increased when performed during pregnancy, and when performed before pregnancy the risk ofPTB is increased, although insignificant.
Pregnancy Outcome After Treatment for Cervical Intraepithelial Neoplasia
TLDR
Women with CIN3 have higher rates of spontaneous preterm delivery and preterm PROM than do those in the general population and should be counseled adequately before treatment but should be reassured regarding the treatment of CIN on the risk of preterm Delivery.
Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis
TLDR
Most CIN2 lesions, particularly in young women (<30 years), regress spontaneously, and active surveillance, rather than immediate intervention, is justified, especially among young women who are likely to adhere to monitoring.
Comparative fertility and pregnancy outcomes after local treatment for cervical intraepithelial neoplasia and stage 1a1 cervical cancer: protocol for a systematic review and network meta-analysis from the CIRCLE group
TLDR
A protocol is presented for a systematic review and network meta-analysis that will update the evidence and compare all treatments in terms of fertility and pregnancy complications and use CINeMA (Confidence in Network meta- analysis) to assess the quality of the evidence for the primary outcome.
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