Obsessive compulsive disorder: Opportunities within and beyond the serotonergic domain.

@article{Zohar1997ObsessiveCD,
  title={Obsessive compulsive disorder: Opportunities within and beyond the serotonergic domain.},
  author={Joseph Zohar and Yehuda Sasson},
  journal={Acta neuropsychiatrica},
  year={1997},
  volume={9 2},
  pages={
          84-6
        }
}
Abnormality of the serotonin (5-hydroxytryptamine - 5-HT) system and particularly hypersensitivity of postsynaptic 5-HT receptors remained the leading hypothesis for the underlying pathophysiology of obsessive compulsive disorder (OCD) during the 1980s. A number of lines of evidence supported this serotonergic hypothesis, not least the treatment studies which demonstrated clearly and consistently that anti-obsessional efficacy was a function of serotonin re-uptake inhibition. Studies of markers… CONTINUE READING
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