Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. A neuropsychological, magnetic resonance imaging and positron tomography study.

@article{Laplane1989ObsessivecompulsiveAO,
  title={Obsessive-compulsive and other behavioural changes with bilateral basal ganglia lesions. A neuropsychological, magnetic resonance imaging and positron tomography study.},
  author={Dominique Laplane and Michele Levasseur and Bernard Pillon and Bruno Dubois and Michel Baulac and Bernard Mazoyer and S Tran Dinh and G Sette and F. Danze and J. C. Baron},
  journal={Brain : a journal of neurology},
  year={1989},
  volume={112 ( Pt 3)},
  pages={699-725}
}
Eight patients are reported who shared the combination of bilateral basal ganglia lesions and a frontal lobe-like syndrome. The main features were inertia and loss of drive, with preservation of intellectual function. Some patients showed stereotyped activities with compulsive and obsessive behaviour which were sometimes highly elaborate in pattern. Extrapyramidal clinical signs were absent or mild. Brain damage, related to anoxic or toxic encephalopathy, was demonstrated by CT scans and MRI… CONTINUE READING

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