Obsessive-Compulsive Disorder, Impulse Control Disorders and Drug Addiction

  title={Obsessive-Compulsive Disorder, Impulse Control Disorders and Drug Addiction},
  author={Leonardo Franklin Fontenelle and Sanne Oostermeijer and Ben J. Harrison and Christos Pantelis and Murat Y{\"u}cel},
The basic concepts underlying compulsive, impulsive and addictive behaviours overlap, which may help explain why laymen use these expressions interchangeably. Although there has been a large research effort to better characterize and disentangle these behaviours, clinicians and scientists are still unable to clearly differentiate them. Accordingly, obsessive-compulsive disorder (OCD), impulse control disorders (ICD) and substance-related disorders (SUD) overlap on different levels, including… 

Compulsivity in Alcohol Use Disorder and Obsessive Compulsive Disorder: Implications for Neuromodulation

Findings supporting common mechanisms between AUD and OCD are reviewed, dissecting the construct of compulsivity and focusing specifically on characteristic disruptions in habit learning and cognitive control in the two disorders.

Habitual versus affective motivations in obsessive-compulsive disorder and alcohol use disorder

Whether the Habit, Reward, and Fear Scale is able to generate a 3-factor solution in a population of obsessive-compulsive disorder and alcohol use disorder patients is confirmed and subgroups that do not match perfectly motivations that usually described in OCD and AUD patients are identified.

The Obsessive-Compulsive Dimension

Heterogeneous aspects of OCD have led to a search for OCD subtypes that might be associated with different aetiologies or treatment responses, as symptomatic presentations and comorbidity patterns differ widely among patients.



Frontal–striatal abnormalities underlying behaviours in the compulsive–impulsive spectrum

Obsessive-compulsive spectrum disorders

These concepts and several representative obsessive-compulsive spectrum disorders including both compulsive and impulsive disorders, as well as the three different symptom clusters: OCD, body dysmorphic disorder, pathological gambling, sexual compulsivity, and autism spectrum disorders are reviewed.

Impulse control disorders in patients with obsessive–compulsive disorder

When OCD is found in association with ICD, the clinical picture is characterized by a greater severity of the obsessive–compulsive symptoms at presentation and by the requirement of a greater number of therapeutic attempts during follow up.

Understanding Obsessive–Compulsive Disorder: Focus on Decision Making

The role of decision-making deficits in the evolution of OCD requires further research, but the collected findings have significant implications for understanding the clinical and behavioral heterogeneity that characterizes individuals with OCD.

Possible role of neuropeptides in obsessive compulsive disorder

On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder

  • M. Carlsson
  • Psychology, Biology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2001

Probing Compulsive and Impulsive Behaviors, from Animal Models to Endophenotypes: A Narrative Review

It is suggested that impulsivity and compulsivity each seem to be multidimensional, and Serotonin and dopamine interact across these circuits to modulate aspects of both impulsive and compulsive responding and as yet unidentified brain-based systems may also have important functions.

Do Obsessive-Compulsive Patients and Abstinent Heroin Addicts Share a Common Psychophysiological Mechanism?

The present findings suggest that both OCD and long-term abstinent heroin addicts may share a common impairment of WM and/or attention involving or affecting the right prefrontal areas.