Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

@article{Pauls2014ObsessivecompulsiveDA,
  title={Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective},
  author={D. Pauls and A. Abramovitch and S. Rauch and D. Geller},
  journal={Nature Reviews Neuroscience},
  year={2014},
  volume={15},
  pages={410-424}
}
Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and behaviours that are experienced as unwanted. Family and twin studies have demonstrated that OCD is a multifactorial familial condition that involves both polygenic and environmental risk factors. Neuroimaging studies have implicated the cortico–striato–thalamo–cortical circuit in the pathophysiology of the disorder, which is supported by the observation of specific neuropsychological impairments in patients with OCD… Expand
View on Nature
neuropsychopathology.com
405 Citations
Highly Influential Citations
34
Background Citations
150
Methods Citations
7
Results Citations
20

405 Citations

Citation Type

Citation Type

Genetic and epigenetic architecture of Obsessive-Compulsive Disorder: In search of possible diagnostic and prognostic biomarkers.
Neuroimaging of psychotherapy for obsessive–compulsive disorder: A systematic review
Obsessive-Compulsive Disorder Genetics: Current and Future Directions
“How Do I Stop Checking Things?” Understanding Obsessive-Compulsive Disorder from Neuropsychological Perspective
Obsessive Compulsive Disorder (OCD) In Childhood and Adolescence
Obsessive-compulsive disorder in children and adolescents
Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology
Animal models of obsessive–compulsive disorder: utility and limitations
The Role of Stress in the Pathogenesis and Maintenance of Obsessive-Compulsive Disorder
Learning From Animal Models of Obsessive-Compulsive Disorder
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 234 REFERENCES
The genetics of obsessive compulsive disorder: A review of the evidence
  • D. Pauls
  • Biology, Medicine
  • American journal of medical genetics. Part C, Seminars in medical genetics
  • 2008
Neurobiology of obsessive–compulsive disorder: insights into neural circuitry dysfunction through mouse genetics
  • J. Ting, G. Feng
  • Psychology, Medicine
  • Current Opinion in Neurobiology
  • 2011
Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
Neuropsychological performance in obsessive-compulsive disorder: a critical review
The role of glutamate signaling in the pathogenesis and treatment of obsessive–compulsive disorder
The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers
The genetics of obsessive-compulsive disorder: a review
  • D. Pauls
  • Psychology, Medicine
  • Dialogues in clinical neuroscience
  • 2010
Neuroimaging and neuropsychological findings in pediatric obsessive-compulsive disorder: a review an
Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS
A meta–analysis of functional neuroimaging in obsessive–compulsive disorder
...
1
2
3
4
5
...