Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

  title={Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective},
  author={David L. Pauls and Amitai Abramovitch and Scott L. Rauch and Daniel A. Geller},
  journal={Nature Reviews Neuroscience},
Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and behaviours that are experienced as unwanted. Family and twin studies have demonstrated that OCD is a multifactorial familial condition that involves both polygenic and environmental risk factors. Neuroimaging studies have implicated the cortico–striato–thalamo–cortical circuit in the pathophysiology of the disorder, which is supported by the observation of specific neuropsychological impairments in patients with OCD… CONTINUE READING
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