Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective

  title={Obsessive–compulsive disorder: an integrative genetic and neurobiological perspective},
  author={David L. Pauls and Amitai Abramovitch and Scott L. Rauch and Daniel A. Geller},
  journal={Nature Reviews Neuroscience},
Obsessive–compulsive disorder (OCD) is characterized by repetitive thoughts and behaviours that are experienced as unwanted. Family and twin studies have demonstrated that OCD is a multifactorial familial condition that involves both polygenic and environmental risk factors. Neuroimaging studies have implicated the cortico–striato–thalamo–cortical circuit in the pathophysiology of the disorder, which is supported by the observation of specific neuropsychological impairments in patients with OCD… 
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The genetics of obsessive compulsive disorder: A review of the evidence
  • D. Pauls
  • Biology, Psychology
    American journal of medical genetics. Part C, Seminars in medical genetics
  • 2008
Twin, family, segregation, and linkage studies have demonstrated that OCD is familial, that the familiality is due in part to genetic factors and there are regions of the genome which very likely harbor susceptibility loci for OCD.
The genetics of obsessive-compulsive disorder: a review
  • D. Pauls
  • Psychology, Biology
    Dialogues in clinical neuroscience
  • 2010
Future research will require the collaboration of multidisciplinary teams of investigators to achieve sufficiently large samples of individuals with OCD; apply the state-of-the-art laboratory techniques; and perform the bioinformatic analyses essential to the identification of risk loci.
Neuroimaging and neuropsychological findings in pediatric obsessive-compulsive disorder: a review an
In examining pediatric OCD, neuropsychological performance may serve as a bridge between brain functioning and the phenomenology of the disorder, highlighting both the neural and cognitive developmental processes within the pediatric population.
Genome-Wide Association Study in Obsessive-Compulsive Disorder: Results from the OCGAS
Assessment of comprehensively assessed OCD patients with an early age of OCD onset revealed association of IQCK and C16orf88, as well as OFCC1 and PTPRD, and follow-up analyses of genome-wide association study signals from a previously published OCD study identified significant enrichment.