Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase.

@article{Hsu2004ObservingTS,
  title={Observing translesion synthesis of an aromatic amine DNA adduct by a high-fidelity DNA polymerase.},
  author={Gerald W. Hsu and James R. Kiefer and Dominique Burnouf and Olivier J. Becherel and Robert P Fuchs and Lorena S. Beese},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 48},
  pages={
          50280-5
        }
}
Aromatic amines have been studied for more than a half-century as model carcinogens representing a class of chemicals that form bulky adducts to the C8 position of guanine in DNA. Among these guanine adducts, the N-(2'-deoxyguanosin-8-yl)-aminofluorene (G-AF) and N-2-(2'-deoxyguanosin-8-yl)-acetylaminofluorene (G-AAF) derivatives are the best studied. Although G-AF and G-AAF differ by only an acetyl group, they exert different effects on DNA replication by replicative and high-fidelity DNA… CONTINUE READING

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