Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat
@article{Bosher1965ObservationsOT, title={Observations on the histological features, development and pathogenesis of the inner ear degeneration of the deaf white cat}, author={S. K. Bosher and Charles Skinner Hallpike}, journal={Proceedings of the Royal Society of London. Series B. Biological Sciences}, year={1965}, volume={162}, pages={147 - 170} }
The histological features, development and pathogenesis of the inner ear degeneration in the deaf white cat has been studied in 57 kittens bred from 4 female and 2 male parent animals. The degeneration makes its appearance between the 4th and 6th day of post-natal life, and up to this time no histological abnormalities can be recognized in the inner ear. The degeneration is confined to the cochlea and saccule. In the cochlea a progressive degeneration of Corti’s organ is seen and appears to be…
107 Citations
Observations on the Histogenesis of the Inner Ear Degeneration of the Deaf White Cat and Its Possible Relationship to the Ætiology of Certain Unexplained Varieties of Human Congenital Deafness
- MedicineThe Journal of Laryngology & Otology
- 1966
Whetnall and Fry (1964) in their recent monograph state that of 1,890 cases of deafness in childhood, the deafnesses in 1,197 could be attributed to some known infection, injury or intoxication such as rubella or neonatal jaundice, leaving a large group of 502 individuals in whom the deafness was entirely unexplained.
Pathologic features of the inner ear in congenital deafness.
- MedicineArchives of otolaryngology
- 1975
The extensive and varied pathologic changes that were present in the patient simultaneously suggest a congenital abnormality in endolymph production and raise the possibility of anomalous development of the labyrinthine vasculature.
Hereditary deafness in the cat. An electron microscopic study of the stria vascularis and Reissner's membrane
- BiologyArchives of oto-rhino-laryngology
- 2004
The basal processes of the marginal cells fail to develop in pathological ears, and appear displaced towards the endolymphatic surface by a layer of grossly swollen, chromophobe cells.
The pattern of sensorineural degeneration in the cochlea of the deaf shaker-1 mouse: ultrastructural observations.
- BiologyBrain research
- 1983
Animal models of inner ear vascular disturbances.
- Medicine, BiologyAmerican journal of otolaryngology
- 1986
Effects of congenital deafness in the cochlear nuclei of Shaker-2 mice: An ultrastructural analysis of synapse morphology in the endbulbs of Held
- BiologyJournal of neurocytology
- 2003
Endbulbs of Held in 7-month old, deaf sh2 mice exhibited fewer synaptic vesicles in the presynaptic ending, the loss of intercellular cisternae, and a hypertrophy of associated postsynaptic densities, consistent with the idea that they represent a generalized response to deafness.
LXIX The Differentiation of Acquired Congenital from Genetically Determined Inner Ear Deafness
- MedicineThe Annals of otology, rhinology, and laryngology
- 1966
The histopathological findings in genetically determined inner ear deafness which is present at or occurs near the time of birth can be divided into two main groups. One group is characterized by…
Cochlear morphology in a strain of the waltzing guinea pig.
- Biology, MedicineActa oto-laryngologica
- 1971
The morphology of the cochlear degenerative process was studied in a strain of the waltzing guinea pig with a dominant mode of inheritance and it may be that this endogenous sensory cell degeneration is caused by an i...
Separate forms of pathology in the cochlea of congenitally deaf white cats
- MedicineHearing Research
- 2003
Ultrastructural analysis of primary endings in deaf white cats: Morphologic alterations in endbulbs of held
- BiologyThe Journal of comparative neurology
- 1997
Studying the synaptic characteristics of the endbulb of Held, a prominent auditory nerve terminal in the cochlear nucleus, reveals that early‐onset, long‐term deafness produces unambiguous alterations in synaptic structure and may be relevant to rehabilitation strategies that promote aural/oral communication.
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