Corpus ID: 847387

Observations on the effects of a new diuretic--S1520.

  title={Observations on the effects of a new diuretic--S1520.},
  author={B. Goldberg and K. Furman},
  journal={South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde},
  volume={48 4},
  • B. Goldberg, K. Furman
  • Published 1974
  • Medicine
  • South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
S1520, a sulphonamide-derived diuretic, was administered to healthy volunteers and patients with oedema. A therapeutic effect was produced by doses of 10 - 20 mg. The onset of action was within 3 hours and persisted for up to 36 hours. Natriuresis, chloruresis and increasing kaliuresis were observed with continued administration. The probable site of drug action was on the distal tubule. Patients with severe renal failure or hyponatraemia did not show a therapeutic response, and the maximal… Expand
10 Citations

Topics from this paper

Clinical efficacy and safety of indapamide in essential hypertension.
Chapter 8: Diuretics
Antihypertensive activity of a new agent, indapamide: a double-blind study.