Observations on the disposition of probenecid in patients receiving allopurinol.

@article{Tjandramaga1972ObservationsOT,
  title={Observations on the disposition of probenecid in patients receiving allopurinol.},
  author={T. Budya Tjandramaga and Samuel A. Cucinell and Zafar H. Israili and James M. Perel and Peter G. Dayton and Ts'ai-fan Y{\"u} and Alexander B. Gutman},
  journal={Pharmacology},
  year={1972},
  volume={8 4},
  pages={
          259-72
        }
}
The effect of allopurinol on the metabolism of pro benecid was evaluated in patients for two reasons: allopurinol was re ported to inhibit drug metabolism, and combined therapy (allopurinol and probenecid) is occasionally employed in the treatment of gout. Metabolism of probenecid was estimated by the determination of probenecid plasma level decay (T½). ln 8 of 14 subjects, a prolongation of T½ was found during concurrent allopurinol treatment. Allopurinol isboth a substrate and an inhibitor of… 
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