Observations on morphologic changes in the aging and degenerating human disc: Secondary collagen alterations

@article{Gruber2002ObservationsOM,
  title={Observations on morphologic changes in the aging and degenerating human disc: Secondary collagen alterations},
  author={Helen E. Gruber and Edward N. Jr. Hanley},
  journal={BMC Musculoskeletal Disorders},
  year={2002},
  volume={3},
  pages={9 - 9}
}
BACKGROUND In the annulus, collagen fibers that make up the lamellae have a wavy, planar crimped pattern. This crimping plays a role in disc biomechanical function by allowing collagen fibers to stretch during compression. The relationship between morphologic changes in the aging/degenerating disc and collagen crimping have not been explored. METHODS Ultrastructural studies were performed on annulus tissue from 29 control (normal) donors (aged newborn to 79 years) and surgical specimens from… CONTINUE READING
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Spinal degeneration: Pathogenesis and Medical Management. In: The Adult Spine

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Highly Influential
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Spinal degeneration : Pathogenesis and Medical Management

  • F Fraser, J Bleasel, R Moskowitz
  • Principles and Practices
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