Observations on Levitt's "new theory of transport".

Abstract

Levitt (1974) (Biochim. Biophys. Acta 373, 115--131) has recently developed a "New Theory of Transport for Cell Membrane Pores" based on the supposition that equivalent pores in the red cell membrane are so small that water and small solute molecules such as urea can not pass each other. Levitt's concept is based on the implicit assumption that urea and water are spherical molecules. We have shown, using a scale model, that Levitt's supposition is not in agreement with the actual molecular shapes. Levitt has further asserted that there is a serious methodological error in measurements reported fifteen years ago by Goldstein and Solomon (1960) (J. Gen. Physiol. 44, 1--17). We have shown that the supposed "methodological error" lies in the fact that Levitt made his mathematical analysis of the appropriate equations under conditions significantly different from those employed by Goldstein and Solomon. A computer solution of the equations under the actual conditions used shows that Levitt's assertion is not justified.

Statistics

05001000'77'80'84'88'92'96'00'04'08'12'16
Citations per Year

342 Citations

Semantic Scholar estimates that this publication has 342 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Solomon1975ObservationsOL, title={Observations on Levitt's "new theory of transport".}, author={A. K. Solomon and J M Milgram and D. Kirkwood}, journal={Biochimica et biophysica acta}, year={1975}, volume={406 1}, pages={157-60} }