Observations of cattle, goats and pigs after administration of synthetic interferon inducers and subsequent exposure to foot and mouth disease virus.

@article{McVicar1973ObservationsOC,
  title={Observations of cattle, goats and pigs after administration of synthetic interferon inducers and subsequent exposure to foot and mouth disease virus.},
  author={J. W. McVicar and J. Y. Richmond and Charles H. Campbell and Linda D. Hamilton},
  journal={Canadian journal of comparative medicine : Revue canadienne de medecine comparee},
  year={1973},
  volume={37 4},
  pages={362-8}
}
Polyriboinosinic-polyribocytidylic acid (poly [rI.rC]) was administered intravenously to 11 cattle and 13 goats in doses of 0.25 to 4.0, and 1.0 to 5.0 mg/kg, respectively. Subsequent exposure of these and untreated control animals to foot and mouth disease virus (FMDV) failed to demonstrate any differences in either the course or severity of the disease. Serum interferon was detected in cattle one hour after the intravenous administration of poly (rI.rC). Six pigs given 4, 20, or 100 mg/kg of… CONTINUE READING