Observations of branched-chain amino acid administration in humans.

  title={Observations of branched-chain amino acid administration in humans.},
  author={Dwight E Matthews},
  journal={The Journal of nutrition},
  volume={135 6 Suppl},
Since the in vitro study of Buse and Reid in 1975 showing a stimulatory effect of leucine upon rat muscle protein synthesis and reduction in proteolysis, a similar effect has been sought in humans. In 1978, Sherwin demonstrated in humans an improvement in N balance with infusion of leucine in obese subjects fasting to lose weight. A variety of subsequent studies have been performed in humans where leucine alone or the BCAAs have been administered in varying amounts and durations, and the effect… CONTINUE READING


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