Observational studies of dopamine D1 and D2 agonists in squirrel monkeys

  title={Observational studies of dopamine D1 and D2 agonists in squirrel monkeys},
  author={Sharon J Rosenzweig-Lipson and Paul E. Hesterberg and Jack Bergman},
The behavioral effects of selective D1 and D2, nonselective, and indirectly acting dopamine agonists were compared in squirrel monkeys using continuous observation procedures. D1 agonists including SKF 81297, SKF 82958, andR(+)-6-Br-APB produced dose-dependent increases in the frequencies of stationary postures and head movements and had little or no effect on either huddling or scratching. In contrast, SKF 75670 andR-SKF 38393, which are considered to be D1 partial agonists, had effects… 
Self-administration of D1 receptor agonists by squirrel monkeys
The results suggest that the ability of D1 agonists to maintain IV self-administration in squirrel monkeys depends both on the type of schedule and on the pharmacological properties of the particular drug.
Effects of Dopamine D1 Ligands on Eye Blinking in Monkeys: Efficacy, Antagonism, and D1/D2 Interactions
Eye blink rate appears to be a robust behavioral measure that can be used to measure changes in dopaminergic D1 signaling and as a functional assay of agonist efficacy at dopamine D1 receptors.
Reinforcing and Stimulant-Like Effects of Methamphetamine Isomers in Rhesus Macaques
L-MA demonstrated lower abuse liability compared to commonly abused stimulants and produced few untoward effects, which support l-MA's potential as a pharmacotherapy for stimulant addiction.
Mu opioid receptor mRNA in nucleus accumbens is elevated following dopamine receptor activation
DA agonists mimick the effect of cocaine on the expression of MOR mRNA in male Sprague-Dawley rats, and this data confirm the involvement of dopaminergic mechanisms in the mediation of cocaine effects, indicate the comparability of actions of indirect and direct DA agonists, and point to the usefulness of cocaine as a tool to expose interaction between dopamine and opioid systems.
Medications for stimulant abuse: agonist-based strategies and preclinical evaluation of the mixed-action D-sub-2 partial agonist aripiprazole (Abilify).
  • J. Bergman
  • Psychology, Biology
    Experimental and clinical psychopharmacology
  • 2008
The present findings indicate that agonist and antagonist effects of aripiprazole are evident under different experimental conditions and that, like D-sub-2 full agonists, aripIPrazole may have limited value for treating monoaminergic stimulant abuse and addiction.
The monoamine reuptake inhibitor BTS 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in MPTP‐treated primates
BTS 74 398 reverses motor abnormalities in MPTP‐treated marmosets without evoking established dyskinesia but no additive improvement occurs when administered in combination with L‐dopa, which may suggest different sites of drug action.
Repetitive Behaviors in Monkeys Are Linked to Specific Striatal Activation Patterns
It is suggested that in the primate, compartmentally and regionally specific striatal activation patterns contribute to the striatal modulation of psychostimulant-induced behaviors.
Effects of acute administration of DA agonists on locomotor activity: MPTP versus neonatal intracerebroventricular 6-OHDA treatment
The effects of several dopamine (DA) receptor agonists upon locomotor activity on adult MPTP-treated mice and postnatal 6-hydroxydopamine-(6-OHDA-) treated rats were assessed in ten experiments, pertaining to their more-or-less selective subreceptor profiles.
Behavioural supersensitivity following neonatal 6-hydroxydopamine: Attenuation by MK-801
The present findings confirm the influence of non-competitive glutamate antagonists in attenuating the behavioural supersensitivity to dopamine antagonists and induce different effects on the motor activity of 6-OHDA-treated and sham-operated mice.
Dynamics and Functional Role of Dopaminergic Neurons in the Ventral Tegmental Area during Itch Processing
Itchiness triggers a strong urge to engage in scratching behavior, which could lead to severe skin or tissue damage in patients with chronic itch, and dopaminergic neurons in the ventral tegmental area play a critical role in modulating itch-induced scratching behavior.


Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats.
The results suggest that D1 receptor tonus is a necessary prerequisite for the expression of a DA agonist's effect, but stronger D1 stimulation is necessary to induce oral stereotypy.
Differential effects of D1 and D2 agonists in MPTP‐treated primates
The findings clearly indicate that D2 receptor stimulation appears essential for antiparkinsonian activity, and also implicate D2 receptors in the genesis of dystonia, but not chorea.
Selective effects of the D1 dopamine receptor agonist, SKF 38393, on behavior maintained by cocaine injection in squirrel monkeys
It is suggested that indirect D1-receptor activation plays a role in the reinforcing effects of cocaine, and that drugs acting at D1 receptors may show promise as therapeutic agents in the treatment of cocaine abuse.
Stimulus properties of dopaminergic drugs: comparisons involving selective agonists and antagonists.
The results suggest that the stimulus properties of a variety of neuropharmacologically important and clinically useful compounds are transduced at (pre- or postsynaptic) D2 receptors, but this conclusion must be tempered by evidence that actions at D1 and D2 receptor may not be entirely independent.
Interaction of haloperidol and SCH 23390 with cocaine and dopamine receptor subtype-selective agonists on schedule-controlled behavior of squirrel monkeys
The results suggest that independent stimulation of either D1 or D2 receptors alone does not play a major role in the effects of cocaine on schedule-controlled behavior of squirrel monkeys.
Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets
The ability of both SKF 38393 and SCH 23390 to inhibit quinpirole locomotor activity suggests some interaction between D-1 and D-2 systems to occur in this species.
Effects of the putative D-1 antagonist SCH 23390 on stereotyped behaviour induced by the D-2 agonist RU24213
Data are consistent with blockade of tonic D-1 dopaminergic activity that may influence the expression of behaviours initiated by D-2 dopaminerential stimulation.
Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297
A range of selective dopamine Dl and D2 receptor agonists and antagonists was used to characterize the discriminative stimuli produced by d-amphetamine and the Dl agonist SKF 81297, which had a 25-fold greater potency than SKF 38393 in this assay.