Observation versus antiplatelet therapy as primary prophylaxis for thrombosis in low-risk essential thrombocythemia.

@article{lvarezLarrn2010ObservationVA,
  title={Observation versus antiplatelet therapy as primary prophylaxis for thrombosis in low-risk essential thrombocythemia.},
  author={Alberto {\'A}lvarez-Larr{\'a}n and Francisco Cervantes and Arturo Pereira and Eduardo Arellano-Rodrigo and Virginia P{\'e}rez-Andreu and Juan-Carlos Hern{\'a}ndez-Boluda and Ram{\'o}n Ayats and Carlos C. Salvador and Ana Munta{\~n}ola and Beatriz Bellosillo and Vicente Vicente and Luis Hern{\'a}ndez-Nieto and Carmen Burgaleta and Blanca Xicoy and Carlos Besses},
  journal={Blood},
  year={2010},
  volume={116 8},
  pages={1205-10; quiz 1387}
}
The effectiveness of antiplatelet therapy as primary prophylaxis for thrombosis in low-risk essential thrombocythemia (ET) is not proven. In this study, the incidence rates of arterial and venous thrombosis were retrospectively analyzed in 300 low-risk patients with ET treated with antiplatelet drugs as monotherapy (n = 198) or followed with careful observation (n = 102). Follow-up was 802 and 848 person-years for antiplatelet therapy and observation, respectively. Rates of thrombotic events… CONTINUE READING
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Pathogenesis and management of essential thrombocythemia.

Hematology. American Society of Hematology. Education Program • 2009
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