Observation of strange kinetics in protein folding.

  title={Observation of strange kinetics in protein folding.},
  author={Jobiah J Sabelko and John B. Ervin and Martin Gruebele},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 11},
Highly nonexponential folding kinetics in aqueous solution have been observed during temperature jump-induced refolding of two proteins, yeast phosphoglycerate kinase and a ubiquitin mutant. The observations are most easily interpreted in terms of downhill folding, which posits a heterogeneous ensemble of structures en route to the folded state. The data are also reconciled with exponential kinetics measured under different experimental conditions and with titration experiments indicating… CONTINUE READING