Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex.

Abstract

HIV-1 protease is an effective target for the design of drugs against AIDS. To help this process of drug design, three-dimensional structures have been determined of complexes between HIV-1 protease and a variety of transition-state analogue inhibitors. The true transition state, however, has not been structurally characterized. The crystal structure of the… (More)

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@article{Kumar2005ObservationOA, title={Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex.}, author={Mukesh Kumar and Vishal Prashar and Smita D. Mahale and Madhusoodan Vijayacharya Hosur}, journal={The Biochemical journal}, year={2005}, volume={389 Pt 2}, pages={365-71} }