Observation of a stable carbene at the active site of a thiamin enzyme.

Abstract

Carbenes are highly reactive chemical compounds that are exploited as ligands in organometallic chemistry and are powerful organic catalysts. They were postulated to occur as transient intermediates in enzymes, yet their existence in a biological system could never be demonstrated directly. We present spectroscopic and structural data of a thiamin enzyme in… (More)
DOI: 10.1038/nchembio.1275

Cite this paper

@article{Meyer2013ObservationOA, title={Observation of a stable carbene at the active site of a thiamin enzyme.}, author={Danilo Meyer and Piotr Neumann and Ralf Ficner and Kai Tittmann}, journal={Nature chemical biology}, year={2013}, volume={9 8}, pages={488-90} }