Obscurin is a ligand for small ankyrin 1 in skeletal muscle.

  title={Obscurin is a ligand for small ankyrin 1 in skeletal muscle.},
  author={Aikaterini Kontrogianni-Konstantopoulos and Ellene M Jones and Damian B. van Rossum and Robert J Bloch},
  journal={Molecular biology of the cell},
  volume={14 3},
The factors that organize the internal membranes of cells are still poorly understood. We have been addressing this question using striated muscle cells, which have regular arrays of membranes that associate with the contractile apparatus in stereotypic patterns. Here we examine links between contractile structures and the sarcoplasmic reticulum (SR) established by small ankyrin 1 (sAnk1), a approximately 17.5-kDa integral protein of network SR. We used yeast two-hybrid to identify obscurin, a… CONTINUE READING