Obscure functions: the location–function relationship of obscurins

@article{Manring2017ObscureFT,
  title={Obscure functions: the location–function relationship of obscurins},
  author={Heather R. Manring and Olivia A. Carter and Maegen A. Ackermann},
  journal={Biophysical Reviews},
  year={2017},
  volume={9},
  pages={245-258}
}
The obscurin family of polypeptides is essential for normal striated muscle function and contributes to the pathogenesis of fatal diseases, including cardiomyopathies and cancers. The single mammalian obscurin gene, OBSCN, gives rise to giant (∼800 kDa) and smaller (∼40–500 kDa) proteins that are composed of tandem adhesion and signaling motifs. Mammalian… CONTINUE READING