Obligatory role of cyclic adenosine monophosphate response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators.

@article{Schroer2002ObligatoryRO,
  title={Obligatory role of cyclic adenosine monophosphate response element in cyclooxygenase-2 promoter induction and feedback regulation by inflammatory mediators.},
  author={Karsten Schroer and Ying Zhu and Michael A Saunders and Wu-guo Deng and Xiao-ming Xu and Jutta Meyer-Kirchrath and Kenneth K. Wu},
  journal={Circulation},
  year={2002},
  volume={105 23},
  pages={2760-5}
}
BACKGROUND Cyclooxygenase-2 (COX-2) plays a key role in human inflammatory disorders such as vascular inflammation. COX-2 promoter activity is induced by proinflammatory mediators, but the role of cyclic adenosine monophosphate response element (CRE) in promoter stimulation remains unclear. METHODS AND RESULTS Transient transfection of a 0.9-kb COX-2… CONTINUE READING