Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.

@article{Ottschytsch2002ObligatoryHO,
  title={Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.},
  author={Natacha Ottschytsch and Adam Raes and Diane Van Hoorick and Dirk Snyders},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 12},
  pages={7986-91}
}
Voltage-gated K(+) channels control excitability in neuronal and various other tissues. We identified three unique alpha-subunits of voltage-gated K(+)-channels in the human genome. Analysis of the full-length sequences indicated that one represents a previously uncharacterized member of the Kv6 subfamily, Kv6.3, whereas the others are the first members of two unique subfamilies, Kv10.1 and Kv11.1. Although they have all of the hallmarks of voltage-gated K(+) channel subunits, they did not… CONTINUE READING

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