Obligate mitogen-activated protein kinase activation in parathyroid hormone stimulation of calcium transport but not calcium signaling.

@article{Sneddon2000ObligateMP,
  title={Obligate mitogen-activated protein kinase activation in parathyroid hormone stimulation of calcium transport but not calcium signaling.},
  author={W. Bruce Sneddon and Fengming Liu and Frank A. Gesek and Peter A Friedman},
  journal={Endocrinology},
  year={2000},
  volume={141 11},
  pages={
          4185-93
        }
}
PTH regulates calcium homeostasis through direct actions on its cognate type I receptor in the kidney and bone. PTH inhibits phosphate transport in renal proximal (PCT) tubules and stimulates calcium absorption by distal convoluted tubules (DCT). We examined PTH activation of the mitogen-activated protein kinase (MAPK) cascade raf-MEK-ERK in PCT and DCT cells and its effects on calcium transport and signaling. In DCT cells, PTH stimulates phosphorylation of ERK2 and activation of ERK2 kinase… CONTINUE READING

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