Objective scoring of transformed foci in BALB/c 3T3 cell transformation assay by statistical image descriptors.

@article{Urani2013ObjectiveSO,
  title={Objective scoring of transformed foci in BALB/c 3T3 cell transformation assay by statistical image descriptors.},
  author={Chiara Urani and Raffaella Corvi and Giulia Callegaro and Federico M. Stefanini},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2013},
  volume={27 6},
  pages={
          1905-12
        }
}
In vitro cell transformation assays (CTAs) have been shown to model important stages of in vivo carcinogenesis and have the potential to predict carcinogenicity in humans. Advantages of CTAs are their ability of revealing both genotoxic and non-genotoxic carcinogens while reducing both experimental costs and the number of animals used. The endpoint of the CTA is foci formation, and requires classification under light microscopy based on morphology. Thus current limitations for the wide adoption… CONTINUE READING
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