Objective measurement of topically applied corticosteroids.

@article{Kirly1976ObjectiveMO,
  title={Objective measurement of topically applied corticosteroids.},
  author={Katalin Kir{\'a}ly and Gy. So{\'o}s},
  journal={Dermatologica},
  year={1976},
  volume={152 Suppl 1},
  pages={
          133-7
        }
}
The vasoconstriction caused by four topical corticosteroid preparations was compared according to subjective ranking and according to measurement by a tristimulus colourimeter (Momcolor). The measured results agreed well with visual evaluation. The colourimeter was proved to be measuring the degree of vasoconstriction. Among the preparations examined, the vasoconstriction effected by hydrocortisone 17-butyrate cream (Locoid) and by betamethasone dipropionate ointment (Diprosone) was stronger… 
Quantification of skin‐colour changes induced by topical corticosteroid preparations using the Minolta Chroma Meter
TLDR
The Minolta Chroma Meter CR‐200 appears to be a simple and accurate device for objectively measuring the blanching effects of topical corticosteroid potency and L* was a more discriminative parameter than a*.
Quantitative Skin Blanching Assay of Corticosteroid Creams Using Tristimulus Colour Analysis
  • S. Chan, A. Po
  • Medicine
    The Journal of pharmacy and pharmacology
  • 1992
TLDR
It is proposed that this multiple‐point skin blanching assay of topical corticosteroids using an internationally accepted clear measurement standard and the subsequent data analysis be adopted as a standard protocol.
Colorimetric Evaluation of the Human Skin Blanching Assay
TLDR
Normal skin color changes occur as consequences of either vascular or pigmentary modifications, and vasoconstriction-induced blanching and disturbances of the melanin system have remained difficult to quantity objectively.
Clinical Pharmacology and Pharmacokinetic Properties of Topically Applied Corticosteroids
  • K. Goa
  • Biology, Medicine
    Drugs
  • 2012
TLDR
Although some gaps still persist in present knowledge of the pharmacology and pharmacokinetics of this important class of drugs, there can be no denying the contribution of topical corticosteroids to the therapy of dermatoses.
Strategies for the Bioequivalence Assessment of Topical Dermatological Dosage Forms
TLDR
Application of the HSBA, Tape Stripping and Dermal Microdialysis for the assessment of bioequivalence is described and the theoretical basis and prognosis for each technique is presented.
Methods for the Assessment of Bioequivalence of Topical Dosage Forms: Correlations, Optimization Strategies, and Innovative Approaches
TLDR
The VCA and its features and requirements are described including data from visual assessment which are now currently considered obsolete and the more acceptable instrumental method using a chromameter, and the dermatopharmacokinetic approach using tape stripping are described.
The skin blanching assay with halcinonide, influence of halcinonide concentration and application time ⋆
Objective Instrumental colour readings (Minolta Chromameter CR200) were performed in order to quantify corticosteroid induced skin blanching.
Methylprednisolone Aceponate
TLDR
Initial findings suggest that methylprednisolone aceponate has potential in the treatment of eczema, but more extensive clinical experience is necessary to determine whether methyl Prednisol one acep onate provides additional benefit over other more widely used agents of its class, particularly in terms of possessing a low propensity for systemic effects.
Remarks on the paper by R. Wrench:
  • J. Murray
  • Medicine, Geology
    Archives of Dermatological Research
  • 2004