Objective assessments of longitudinal outcome in Gilles de la Tourette’s syndrome

  title={Objective assessments of longitudinal outcome in Gilles de la Tourette’s syndrome},
  author={Eric J. Pappert and Christopher G Goetz and Elan D. Louis and Lucy M. Blasucci and Sue E. Leurgans},
  pages={936 - 940}
Objective: To define the long-term outcome in Gilles de la Tourette syndrome (GTS) using objective rating measures. Background: Previous historical studies suggest spontaneous improvement of tic symptoms after adolescence, but objective longitudinal data are limited. Methods: The authors reviewed all videotapes in their database (1978 through 1991) of children with GTS (ages 8 to 14) who were seen in their tertiary care movement disorder center and underwent a standardized 5-minute filming… 
Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndrome.
Elucidating the Nature and Mechanism of Tic Improvement in Tourette Syndrome: A Pilot Study
Despite a lack of complete tic remission, two subjects exhibited dramatic drops in tic severity that correlated with tic-related disability improvement, and immature patterns of functional connectivity in adult TS subjects were found.
Psychosocial outcome and psychiatric comorbidity
In late adolescence a large sample of individuals who were identified as having Tourette syndrome in childhood and may or may not be in treatment are reassessed, and they are compared with community controls with respect to psychosocial functioning and psychiatric illness.
Tourette's syndrome in adults
Adult patients with Tourette's syndrome had significantly more facial and truncal tics, and a greater prevalence of substance abuse and mood disorders, but fewer phonic tICS, and lower rates of attention‐deficit hyperactivity disorder and oppositional behavior than children with TS.
Long-Term Outcome of Gilles De La Tourette Syndrome
Videotapes recorded 1978 through 1991 of 56 children with Gilles de la Tourette syndrome were reviewed and 31 of the patients were recruited for a second videotape and in-person assessment at Rush-Presbyterian-St Luke’s Movement Disorder Center, Chicago, IL.
What patients with gilles de la tourette syndrome should be treated with deep brain stimulation and what is the best target?
A systematic literature review of the published studies of DBS in GTS suggests that the best candidates are patients with significant functional impairment related to the tic symptoms, who did not respond to conventional pharmacological and behavioral interventions.
Sources of Disability in Tourette Syndrome: Children vs. Adults
  • K. Kompoliti
  • Medicine, Psychology
    Tremor and other hyperkinetic movements
  • 2015
This manuscript reviews the disease-specific Quality of Life (QOL) instruments used to measure disability in TS and the existing literature on sources of functional impairment in children and adults with TS and examines the differential impact of tics vs. the psychiatric co-morbidities.
Gilles de la Tourette syndrome
Future research that integrates clinical and neurobiological data, including neuroimaging and genetics, is expected to reveal the pathogenesis of GTS at the neural circuit level, which may lead to targeted interventions.
Imaging evidence for anatomical disturbances and neuroplastic compensation in persons with Tourette syndrome.


Tics and Gilles de la Tourette's Syndrome: A Follow-up Study and Critical Review
Adolescents who have suffered with tics from an earlier age develop vocal tics and coprolalia (compulsive swearing) symptomatic of Gilles de la Tourette's syndrome.
A rating scale for Gilles de la Tourette's syndrome
The rating scale objectively detected improvement in tics with neuroleptics, the one pharmacotherapy accepted to abate tics in most patients and correlated well with scales used to assess global changes over prolonged periods.
Videotape tic counts in the assessment of Tourette's syndrome: stability, reliability, and validity.
Standardized videotape tic counts can provide highly reliable, stable measures of tic frequencies that are moderately correlated with selected global ratings of ti severity.
Home alone: Methods to maximize tic expression for objective videotape assessments in Gilles de la Tourette syndrome
Whether at‐home videotapes yield enhanced information on tics compared to office‐based videotapes and a patient questionnaire on the current anatomical distribution of tics is tested.
A new instrument for clinical studies of Tourette's syndrome.
A multidimensional scale for rating symptom frequency and disruptiveness in Tourette's syndrome is developed; estimates of inter-rater reliability for specific symptoms and the global score are promising.
Advantages of a modified scoring method for the rush video‐based tic rating scale
Data demonstrate that the modified videotape‐based scoring system retains the essential information gathered in the original Rush scale, and provides comparisons among the five assessed domains and a total objectively based disability score that can be used as a single outcome measure for assessing tic disability.
Tourette syndrome: an analysis of 200 pediatric and adolescent cases.
The clinical profiles of 200 children and adolescents with Tour- ette syndrome are reviewed and a strikingly large number (58%) of these children had learning problems, behavioral problems, or both.
The natural history of Tourette syndrome: A follow‐up study
The majority of the 58 respondents indicated that they had fewer tics as they reached late adolescence or young adulthood, suggesting that the long‐term outcome in many patients with Tourette syndrome may be more optimistic than previously reported.
The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity.
Data from 105 subjects support the construct, convergent, and discriminant validity of the instrument, and indicate that the YGTSS is a promising instrument for the assessment of tic severity in children, adolescents and adults.
The Treatment of Tics in Childhood
  • D. Zausmer
  • Psychology, Medicine
    Archives of disease in childhood
  • 1954
Tics are involuntary movements of the skeletal musculature involving functionally related muscle groups that can be interpreted as biologically purposeful (protective, defensive, or offensive) but serve no apparently useful purpose since their objective is non-existent.