Objective Measures of Prenatal Alcohol Exposure: A Systematic Review

@article{McQuire2016ObjectiveMO,
  title={Objective Measures of Prenatal Alcohol Exposure: A Systematic Review},
  author={Cheryl McQuire and S. Paranjothy and L. Hurt and M. Mann and D. Farewell and A. Kemp},
  journal={Pediatrics},
  year={2016},
  volume={138}
}
CONTEXT: Objective measurement of prenatal alcohol exposure (PAE) is essential for identifying children at risk for adverse outcomes, including fetal alcohol spectrum disorders. Biomarkers have been advocated for use in universal screening programs, but their validity has not been comprehensively evaluated. OBJECTIVE: To systematically review the validity of objective measures of PAE. DATA SOURCES: Thirteen electronic databases and supplementary sources were searched for studies published… Expand
Screening prevalence of fetal alcohol spectrum disorders in a region of the United Kingdom: A population-based birth-cohort study
TLDR
These screening prevalence estimates suggest that FASD is likely to be a significant public health concern in the UK and active case ascertainment studies are urgently needed to further clarify the current epidemiology of FasD in the general population of the UK. Expand
The cost-effectiveness of screening tools used in the diagnosis of fetal alcohol spectrum disorder: a modelled analysis
TLDR
Assessing the cost-effectiveness of currently recommended FASD screening tools suggests that screening is associated with less use of healthcare recourses but also fewer years of life with an FasD diagnosis over a no screening strategy. Expand
A systematic review of prevention interventions to reduce prenatal alcohol exposure and fetal alcohol spectrum disorder in indigenous communities
TLDR
There is little evidence that previous interventions aiming to reduce the risk of prenatal alcohol exposure or FASD in Indigenous populations have been effective, and future intervention studies should address the cultural factors and historical context. Expand
The Standardization of Diagnostic Criteria for Fetal Alcohol Spectrum Disorder (FASD): Implications for Research, Clinical Practice and Population Health
TLDR
This review seeks to analyse the discrepancies in existing diagnostic tools for FASD, and the repercussions these differences have on research, public health, and government policy. Expand
Determining the pattern and prevalence of alcohol consumption in pregnancy by measuring biomarkers in meconium
TLDR
Measurement of ethanol biomarkers in meconium is a feasible tool for determining the pattern and prevalence of alcohol consumption in pregnancy and data suggest that at least 15% of pregnant women in the west of Scotland are consuming significant quantities of alcohol during latter pregnancy. Expand
DNA methylation as a predictor of fetal alcohol spectrum disorder
TLDR
Findings further support the association of FASD with distinct DNA methylation patterns, while providing a possible entry point towards the development of epigenetic biomarkers of FasD. Expand
Early School Years follow up of the Asking Questions in Alcohol Longitudinal Study in Melbourne, Australia (AQUA at 6): Cohort profile
TLDR
The relationship between prenatal alcohol exposure and specific aspects of neurodevelopment at 6-8 years, including brain structure & function is investigated, and whether craniofacial changes identified at 12 months of age are predictive of later developmental impairments is determined. Expand
A review of studies exploring fetal alcohol spectrum disorders through eye tracking measures
TLDR
Eye tracking data showed that FASD are mostly associated with impaired ocular perceptive/motor abilities, lower accuracy as well as increased error rates in saccadic eye movements involving working memory abilities, and reduced inhibitory control on saccades. Expand
A reduction in reported alcohol use in pregnancy in Australian Aboriginal communities: a prevention campaign showing promise.
TLDR
The reduction in reported prenatal alcohol exposure in an Aboriginal community setting during a period of prevention activities provides initial evidence for a community-led strategy that might be applicable to similar communities. Expand
Fetal alcohol spectrum disorders: an overview of current evidence and activities in the UK
TLDR
The current state of play regarding FASD knowledge and research in the UK is outlined, which is characterised by a lack of evidence, a Lack of dedicated funding and services, and consequently little policy formulation and strategic direction. Expand
...
1
2
...

References

SHOWING 1-10 OF 175 REFERENCES
Systematic Review of Fetal Alcohol Spectrum Disorder Interventions Across the Life Span.
TLDR
There is growing evidence for interventions that improve outcomes for early to middle childhood, however, a lack of research exists outside of this developmental period, and the lack of interventions for adolescents and adults further highlights the widening developmental gap. Expand
Brief screening questionnaires to identify problem drinking during pregnancy: a systematic review.
TLDR
T-ACE, TWEAK and AUDit-C show promise for screening for risk drinking, and AUDIT-C may also be useful for identifying alcohol dependency or abuse, however, their performance as stand-alone tools is uncertain, and further evaluation of questionnaires for prenatal alcohol use is warranted. Expand
Biomarkers for detection of prenatal alcohol exposure: a critical review of fatty acid ethyl esters in meconium.
  • L. Burd, Ryan Hofer
  • Medicine
  • Birth defects research. Part A, Clinical and molecular teratology
  • 2008
TLDR
The accurate identification of alcohol-exposed pregnancies represents a significant challenge in the development of FAEE detection cutoffs to maximize the sensitivity and specificity of the test. Expand
The association of mild, moderate, and binge prenatal alcohol exposure and child neuropsychological outcomes: a meta-analysis.
TLDR
The results of this review highlight the importance of abstaining from binge drinking during pregnancy and provide evidence that there is no known safe amount of alcohol to consume while pregnant. Expand
Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
TLDR
The worldwide pooled prevalence estimates are higher than assumed so far, but this was largely explained by geography and descent, and clear guidelines on assessing FASD prevalence are urgently needed. Expand
A comparison of the prevalence of prenatal alcohol exposure obtained via maternal self-reports versus meconium testing: a systematic literature review and meta-analysis
TLDR
If maternal self-reports are the sole information source upon which health care professionals rely, a number of infants who were prenatally exposed to alcohol are not being recognized as such. Expand
Neonatal screening for prenatal alcohol exposure: assessment of voluntary maternal participation in an open meconium screening program.
TLDR
Despite the potential benefits of such screening programs, maternal unwillingness to consent may limit the effectiveness of meconium testing for population-based open screening, highlighting the need for public education and social marketing efforts for such programs to be of benefit. Expand
Comments and reflections on ethics in screening for biomarkers of prenatal alcohol exposure.
TLDR
Gaps in the literature on screening for PAE are identified, most notably related to a lack of stakeholder perspectives about screening and the ethical challenges it presents, and these must be addressed before the implementation of screening programs. Expand
Ethical and Social Challenges in Newborn Screening for Prenatal Alcohol Exposure
of preventable, non-genetic birth defects and intellectual disability in Canada.1 Presently, the diagnosis of FASD relies heavily on prior documentation and self-reporting of alcohol use by theExpand
Risk Factors for Adverse Life Outcomes in Fetal Alcohol Syndrome and Fetal Alcohol Effects
TLDR
The odds of escaping these adverse life outcomes are increased 2- to 4-fold by receiving the diagnosis of FAS or FAE at an earlier age and by being reared in good stable environments. Expand
...
1
2
3
4
5
...