Objective Cognitive Performance Associated with Electroconvulsive Therapy for Depression: A Systematic Review and Meta-Analysis

  title={Objective Cognitive Performance Associated with Electroconvulsive Therapy for Depression: A Systematic Review and Meta-Analysis},
  author={Maria Semkovska and Declan M. McLoughlin},
  journal={Biological Psychiatry},

Tables from this paper

Cognitive function after electroconvulsive therapy for depression: relationship to clinical response

There was no evidence of persistent impairment of cognition after ECT, and remitted patients had significantly improved self-rated memory, anterograde verbal memory and category verbal fluency compared with those remaining depressed.

A Systematic Review on Cognitive Effects of Electroconvulsive Therapy in Asian Patients

  • Yining OngL. G. Chan
  • Psychology, Medicine
    Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2022
There is no consistent evidence that suggests ECT causes cognitive deficits in patients, despite the widespread use of high dose Bitemporal ECT, and it is suggested that Asian patients, presenting with a different psychiatric profile, may respond to high-dose Bitem temporal ECT differently from Western samples.

Comparative efficacy, cognitive effects and acceptability of electroconvulsive therapies for the treatment of depression: protocol for a systematic review and network meta-analysis

Introduction There have been important advances in the use of electroconvulsive therapy (ECT) to treat major depressive episodes. These include variations to the type of stimulus the brain regions

Electroconvulsive therapy and cognitive functions in treatment-resistant depression

  • A. BodnarM. Krzywotulski J. Rybakowski
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2016
In addition to its antidepressant effect in DRD, ECT may also exert a long-term favourable influence on some cognitive functions in patients with unipolar and bipolar DRD.

A Retrospective Study of Cognitive Improvement Following Electroconvulsive Therapy in Schizophrenia Inpatients.

The study provided support to the existing literature where cognitive improvement has been reported among individuals with schizophrenia after ECT and the Brief ECT Cognitive Screen may be useful as a quick measure to detect such ECT-related cognitive change.

Effect of Donepezil on Cognitive Deficits Associated With Electroconvulsive Therapy: A Randomized Triple-blind Clinical Trial

This study did not find an effect in patients under ECT of acetylcholinesterase inhibitors in improving cognitive defects related to ECT, and further studies are required to reach a clear conclusion.

Anterograde Amnesia during Electroconvulsive Therapy: A Prospective Pilot-Study in Patients with Major Depressive Disorder

If these findings can be reproduced in a more comprehensive study group, then the possible induction of anterograde amnesia is not a justifiable reason for clinicians to disregard ECT as a treatment option.

Current Practices of Electroconvulsive Therapy in Mental Disorders: A Systematic Review and Meta-Analysis of Short and Long-Term Cognitive Effects.

A systematic review and meta-analysis of the most frequent cognitive side effects after ECT found no significant changes in global cognition with Mini-Mental State Examination at PO1, but there is a lack of standardization in the choice of cognitive tests and optimal cognitive timing.

The Role of Baseline Cognitive Function in the Neurocognitive Effects of Electroconvulsive Therapy in Depressed Elderly Patients

Electroconvulsive therapy is an effective biological treatment option for severely depressed elderly patients; however, it can cause cognitive side effects, including anterograde and retrograde amnesia, which elderly patients with CIND were not more vulnerable to amnesia.



The Cognitive Effects of Electroconvulsive Therapy in Community Settings

A prospective, naturalistic, longitudinal study of clinical and cognitive outcomes in patients with major depression treated at seven facilities in the New York City metropolitan area.

Memory, Attention, and Executive Functions Before and After Sine and Pulse Wave Electroconvulsive Therapies for Treatment-Resistant Major Depression

Anterograde memory improved to a statistically significant or nonsignificant degree at 1 week post-ECT in comparison with pre-ECT regardless of waveforms, and attention/executive functions tended to deteriorate with sineWave ECT but improved with pulse wave ECT.

The Effect of Electroconvulsive Therapy on Autobiographical Memory: A Systematic Review

Evidence suggests that autobiographical memory impairment does occur as a result of ECT and further research is required to determine memory loss associated with ECT, controlling for the direct effects of the depressive state.

Age‐related cognitive effects of ECT and ECT‐induced mood improvement in depressive patients

Investigating the interaction between electroconvulsive therapy treatment‐effect, reduced depression, and neuropsychological outcome in relation to age provides evidence that ECT may improve cognitive functioning in nondemented elderly, which has strong clinical relevance concerning the use of ECT.

Patients' perspectives on electroconvulsive therapy: systematic review

The current statement for patients from the Royal College of Psychiatrists that over 80% of patients are satisfied with electroconvulsive therapy and that memory loss is not clinically important is unfounded.

Neuropsychological effects of electroconvulsive therapy.

Compared pre- and posttreatment performances on the Halstead-Reitan neuropsychological battery of 20 patients who were receiving ECT from two different machines, most Ss gave indicators of cerebral impairment prior to treatment and after treatment, there was an increased number of Ss who evidenced signs consistent with damage to the right cerebral hemisphere.

Cognitive impairment in the euthymic phase of chronic unipolar depression.

Male patients with a history of chronic unipolar disorder are at risk for cognitive impairment in the nonsymptomatic phase of their disease and cognitive disturbance is the type seen with prefrontal dysfunction and may be assessed with standard neuropsychological assessments.

Changes in Everyday and Semantic Memory Function After Electroconvulsive Therapy for Unipolar Depression

A small but reversible decrease in everyday memory occurs after ECT in depressed patients, which is influenced by age and electrode placement, and the semantic memory of older patients receiving ECT for severe mood disorder shows greater improvement at follow-up compared with younger patients.

Seizure Expression During Electroconvulsive Therapy: Relationships with Clinical Outcome and Cognitive Side Effects

Inability to distinguish forms of RUL ECT differing markedly in dosage and efficacy suggests that EEG measures have limited potential as markers of treatment adequacy, and whether EEG features are sensitive to treatment condition using a broad dosing range, as well as predictive of clinical and cognitive outcomes.