Object alternation and orbitofrontal system dysfunction in Alzheimer's and Parkinson's disease

@article{Freedman1990ObjectAA,
  title={Object alternation and orbitofrontal system dysfunction in Alzheimer's and Parkinson's disease},
  author={Morris Freedman},
  journal={Brain and Cognition},
  year={1990},
  volume={14},
  pages={134-143}
}
Previous performance on measures of frontal system function have suggested prominent orbitofrontal system damage in Alzheimer's disease, but not in Parkinson's dementia. Object alternation (OA), a task sensitive to orbitofrontal system dysfunction in non-human animals, was therefore administered to determine whether this measure would distinguish Alzheimer's from Parkinson's dementia. OA was significantly impaired in Alzheimer's disease compared to Parkinson's dementia, even though both groups… CONTINUE READING

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