Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships.


OBJECTIVE The effects of obidoxime in the treatment of organophosphate poisoning were assessed by biochemical and biological effect monitoring. In this article we report effects on neuromuscular function, oxime and atropine concentration, and relate them to acetylcholinesterase (AChE) activity. METHODS We measured the activity of cholinesterase in plasma… (More)
DOI: 10.1080/15563650903206836


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