Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats.

@article{Verbeke2014ObeticholicAA,
  title={Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats.},
  author={Len Verbeke and Ricard Farr{\'e} and Jonel Trebicka and Mina Komuta and Tania A Roskams and Sabine Klein and Ingrid Vander Elst and Petra Windmolders and Tim Vanuytsel and Frederik Nevens and Wim Laleman},
  journal={Hepatology},
  year={2014},
  volume={59 6},
  pages={2286-98}
}
UNLABELLED The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. We studied the effect of short-term treatment with obeticholic acid (INT-747), a potent selective FXR agonist, on intrahepatic hemodynamic dysfunction and signaling pathways in different rat models of cirrhotic portal hypertension (PHT). For this, thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL… CONTINUE READING
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