Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39.

@article{Zhang2008ObestatinIO,
  title={Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39.},
  author={Jian V. Zhang and Holger Jahr and Chin-Wei Luo and Cynthia A Klein and Kristof Van Kolen and Luc Ver Donck and Ananya De and Esther Baart and Jing Li and Dieder Moechars and Aaron J Hsueh},
  journal={Molecular endocrinology},
  year={2008},
  volume={22 6},
  pages={1464-75}
}
Obestatin was identified as a brain/gut peptide hormone encoded by the ghrelin gene and found to interact with the G protein-coupled receptor, GPR39. We investigated target cells for obestatin based on induction of an early-response gene c-fos in different tissues. After ip injection of obestatin, c-fos staining was found in the nuclei of gastric mucosa, intestinal villi, white adipose tissues, hepatic cords, and kidney tubules. Immunohistochemical analyses using GPR39 antibodies further… CONTINUE READING
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Altered gastrointestinal and metabolic Zhang et al. • Gene Expression and Binding to GPR39 Mol Endocrinol

  • D Moechars, I Depoortere, +8 authors B Coulie
  • Gastroenterology
  • 2006
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