Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels.

@article{Illison2016ObesogenicAD,
  title={Obesogenic and Diabetogenic Effects of High-Calorie Nutrition Require Adipocyte BK Channels.},
  author={Julia Illison and Lijun Tian and Heather McClafferty and Martin W. Werno and Luke H Chamberlain and Veronika Leiss and Antonia Sassmann and Stefan Offermanns and Peter J. van Ruth and Michael J Shipston and Robert Lukowski},
  journal={Diabetes},
  year={2016},
  volume={65 12},
  pages={3621-3635}
}
Elevated adipose tissue expression of the Ca2+- and voltage-activated K+ (BK) channel was identified in morbidly obese men carrying a BK gene variant, supporting the hypothesis that K+ channels affect the metabolic responses of fat cells to nutrients. To establish the role of endogenous BKs in fat cell maturation, storage of excess dietary fat, and body weight (BW) gain, we studied a gene-targeted mouse model with global ablation of the BK channel (BKL1/L1) and adipocyte-specific BK-deficient… CONTINUE READING

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