Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome.

@article{Mangge2014ObesityrelatedDO,
  title={Obesity-related dysregulation of the tryptophan-kynurenine metabolism: role of age and parameters of the metabolic syndrome.},
  author={Harald Mangge and Kelli L Summers and Andreas Meinitzer and Sieglinde Zelzer and Gunter Almer and Ruth Prassl and Wolfgang J Schnedl and Eva Z Reininghaus and Katharina Paulmichl and Daniel Weghuber and Dietmar Fuchs},
  journal={Obesity},
  year={2014},
  volume={22 1},
  pages={195-201}
}
OBJECTIVE Obesity-related immune mediated systemic inflammation was associated with the development of the metabolic syndrome by induction of the tryptophan (TRP)-kynurenine (KYN) pathway. The study aimed to assess whether this holds true across the lifespan from juvenility to adulthood. DESIGN AND METHODS Five hundred twenty-seven participants aged between 10 and 65 years were analyzed. Standard anthropometric measures, carotid ultrasound, and laboratory analysis including interleukin-6… CONTINUE READING
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